MIB-1 and p27Kip1 Expression in Nephroblastoma

MIB-1 and p27Kip1 expression in nephroblastoma.

MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27 Protein Expression in Nephroblastoma

Purpose: A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27 expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these molecules in Wilms’ tumors. Experimental Design: MIB-1 and p27 expressions were investigated by the means of immunohistochemical analysis of 62...

MIB-1 (KI-67) proliferation index and cyclin-dependent kinase inhibitor p27(Kip1) protein expression in nephroblastoma.

PURPOSE A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27(Kip1) expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these molecules in Wilms' tumors. EXPERIMENTAL DESIGN MIB-1 and p27(Kip1) expressions were investigated by the means of immunohistochemical an...

Immunohistochemical expression of Wilms' tumor 1 protein in nephroblastoma.

BACKGROUND Approximately 10% of nephroblastomas (Wilms' tumors) carry mutations in the Wilms' tumor 1 (WT1) gene. Recently, a WT1 antibody raised against N-terminal 1-181 amino acids of human WT1 became commercially available for immunohistochemical use on paraffin-embedded tissue. The aim of this study was to investigate the diagnostic and prognostic value of WT1 N-terminal antibody in nephrob...

Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma.

Wilms' tumor is one of the most common solid tumors of children. The protein product of the tumor-suppressor gene, Wilms' tumor 1 (WT-1), binds to the same DNA sequences as the protein product of the early growth response 1 (EGR-1) gene. There is experimental evidence that EGR-1 is involved in controlling cell growth. The expression of both genes in Wilms' tumor was studied by others, mainly at...